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Regarding the SEV group, B12-upregulated genes had GO annotations related to cytoplasmic translation (tRNA and rRNA processing), adaptive immune response, ncRNA processing, miRNA-mediated gene silencing, proteasome-mediated ubiquitin-dependent protein catabolic process, cobalamin transport, and negative regulation of transcription by RNA polymerase II ( Figure S3 )

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Both intramuscular and oral administration reduced ulcer area significantly, with higher dosages (400-800 ng/kg) showing inhibition rates between 45.7% and 65.6%

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