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Biotin (B7) is essential for metabolism and growth, whereas folate (B9) is crucial for hematopoiesis, red blood cell formation, carbon transfer, and amino acid metabolism

Meanwhile, in liver failure, impaired lipid biosynthesis results in reduced TG and cholesterol levels, alongside elevated FFA concentrations, thereby aggravating metabolic dysfunction, inflammatory responses, and hepatocellular injury [194,195,196,197]

Vitamin C is an essential nutrient involved in immune function, antioxidant activity, collagen formation, and overall cellular wellness

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Oxidative stress caused by ROS accumulation is sufficient to impair T cell proliferation and self-renewal, resulting in exhaustion [8]