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A serious clinical complication in these patients is the progressive and frequently late-onset dementia noted in this disorder

Glutathione disulfide can be converted back to glutathione in an NADPH-dependent reduction reaction catalyzed by the flavoprotein glutathione reductase (or glutathione-disulfide reductase, GSR

Although the human body can produce glutathione on its own, production can have difficulty keeping up in times of excess stress, immune challenges, unhealthy microbial environments, or during aging, as glutathione status can decline with the natural aging process

Plant Cell 12, 97110

doi: 10.1016/j.molmed.2020.06.006 18 BruntV

Oxidative stress occurs when unstable molecules, often called free radicals, accumulate faster than the body can clear them