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Determining the Right Treatment Plan Treatment Approaches by Multiple Myeloma Stage Goals of Multiple Myeloma Treatment Reduce the amount of M protein (as measured by serum protein electrophoresis) or light chains (as measured via the free light chain test) to the lowest level possible Eliminate myeloma cells from the bone marrow (as measured via minimal residual disease [MRD] testing) Improve quality of life with as few treatment side effects as possible Provide the longest possible period of response before first relapse Prolong overall survival Treatment of Newly Diagnosed Multiple Myeloma Induction therapy Induction therapy, or front-line therapy, typically consists of a three-drug or four-drug combination regimen given over three to four cycles, each of which typically lasts 3 or 4 weeks

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Metabolic radiolabeling with [ 3 H]palmitate [ 3 H]palmitate radiolabeling was performed as previously reported 70

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Additionally, the possibility of interactions with other peptides or compounds highlights the necessity for careful consideration of patient safety and specific needs