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Although reactive electrophiles such as chloroacetamides are generally considered to be promiscuous in target binding, we demonstrated here using a BODIPY-labelled analogue that the chloroacetamide-based GSTO1 inhibitor C1-27 exhibited a low degree of nonspecific reactivity

These features allow them to: (i) passively diffuse between corneocytes (skin cells) due to their small size, (ii) enhance permeation through controlled modifications of surface properties, and (iii) target specific receptors on skin cells using ligands, ultimately leading to deeper delivery of the encapsulated drug

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6D) compared to infected animals from the group receiving the purified standard diet (mean score 2.6 0.4

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