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Citrus fruit and citrus juice have demonstrated platelet inhibition in laboratory studies

The analysis found low doses were as effective as full doses for preventing recurrent VTEs, but low-dose DOAC therapy reduced the risks of major and clinically relevant non-major bleeding events compared with full-dose therapy, with no significant differences between apixaban and rivaroxaban

The changes in glutamate-gated chloride channel subunits, the enhanced expression of efflux transporters, and the changes in parasite metabolism have been identified as the probable contributors to decreased susceptibility to drugs in experimental and field studies (120126)

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Jhaveri A, Deshpande P, Pattni B, Torchilin V