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Elevated TMAO levels, generated from dietary choline via gut microbial metabolism and hepatic flavin monooxygenase-3 conversion, are associated with CVD risk factors including obesity, type 2 diabetes mellitus (T2DM), hyperlipidemia, as well as specific CVD manifestations such as coronary heart disease and myocardial infarction by promoting platelet hyperreactivity, atherosclerosis, and heart failure (Zhu et al., 2016

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Mitochondrial SLC1A5_var inhibition impairs glutamine anaplerosis and redox balance in pancreatic cancer cells To investigate the role of mitochondrial glutamine transport in cancer metabolic reprogramming, we treated cancer cells with iMQT_020 and assessed its effects on glutamine metabolism via 13 C 5 -labeled glutamine (Fig