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This sensitization leads to an augmented secretion of cytokines linked to Th1 and Th17 responses when exposed to pro-inflammatory agents (33)

Not everyone who carries the gene will develop ankylosing spondylitis only 1-2% of individuals with this gene will develop the condition

A systematic review proposed that patients may benefit from rigorous retesting of several agents (e.g., drugs such as -lipoic acid, duloxetine, glutathione, and vitamin E) to extend and validate the evidence of American Society of Clinical Oncology (ASCO) recommendations for CIPN management [82]