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(b) Single small case series in knee pain A peer-reviewed article (Lee et al., Alternative Therapies in Health & Medicine , ~2021) describes: 12 patients with chronic knee pain Treated with intra-articular BPC-157, often combined with TB-500 7 of 12 reported symptom improvement lasting several months This study has major limitations: No control group No blinding No standardized outcomes (no KOOS, WOMAC, or imaging) Very small sample size Mixed interventions Conclusion: This study cannot demonstrate true benefit

Ofwats chief executive, David Black, said of the Thames business plan: Costs were poorly justified, service levels were unsatisfactory and so that makes our job more challenging. He said the response to Thames had been fair and that it was up to Thames to convince investors of its turnaround as it attempts to raise fresh funds