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Rarely observed in MSS and sporadic MSI-CRCs, 2M mutations are present in approximately 3040% of LS-CRCs [7678]

Furthermore, glutathione is involved in various cellular processes, particularly in the liver where it plays a significant role in detoxification

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doi: 10.1242/jcs.260419 209 PodhoreckaMIbanezBDmoszyskaA

As described above, the lack of GSH, although without effect on re-oxidation of roGFP2 in the periplasm, slightly shifted the periplasmic redox homeostasis to more reducing conditions, as seen in the lowered redox potential of roGFP-iL in those cells (Fig