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Thus, while upstream stem cells do have the ability to differentiate into diverse cell types, in ALS, stem cells therapies are now intended to secrete neurotrophic factors, differentiate into astrocytes and microglia, or synapse with diseased motor neurons (Table 6) [271]

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Because of this low oral bioavailability, clinical formulations of ALCAR must be dosed high enough to ensure that an adequate amount of the active compound survives the digestive process and reaches the blood-brain barrier