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On the one hand, they can repair the integrity of the damaged intestinal barrier and promote the enrichment and metabolic activity of protective flora (such as Akkermansia and Lactobacillus ), thereby down-regulating the low-grade chronic inflammation in the whole body and local joints through the gut-joint axis. On the other hand, they can directly inhibit the iron-dependent lipid peroxidation cascade reaction in chondrocytes (such as regulating the GPX4, NRF2 pathways and the expression levels of proteins implicated in iron metabolism) to block or delay the ferroptosis of chondrocytes

Consequently, single-target interventions may only be effective in specific subpopulations

These results suggest that acetone metabolism, which involves cytochrome P-450IIE1, may occur in the lungs and kidneys of hamsters and the nasal mucosa of rabbits

Little solid scientific evidence exists to support claims for alternative therapy benefiting menopausal health

Oral and combination regimens have also shown improvement in melanin indices and overall tone ( Weschawalit et al., Journal of Biomedical Biotechnology, 2017

In others, especially where traditional medicine is widely practiced, there may be greater trust in natural or plant-based antioxidants