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White adipose tissue mass, the fat tissue associated with obesity and metabolic dysfunction, was significantly reduced

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L-type amino acid transporter 1 is associated with chemoresistance in breast cancer via the promotion of amino acid metabolism

doi: 10.1016/j.hoc.2012.02.002 217

Preliminary studies have shown that targeting GLO1 by small molecule inhibitors such as S-p-bromobenzylglutathione cyclopentyl diester (BBGC) significantly inhibits the growth and induces apoptosis of leukemia and other tumor cells, while reversing the resistance of cancer cells to chemotherapeutic drugs (103, 144, 152154)