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As regards DIO2 activation by metformin, the DIO2 activating effect of metformin was demonstrated among others in glial cells and astrocytes in the hypothalamus, where DIO2 catalyses the T4 to T3 reaction

Reflections on the discovery GLP-1 as a satiety hormone: Implications for obesity therapy and future directions

Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: A prognostic marker for incident cardiovascular events beyond traditional risk factors

The greatest weight loss is usually seen after a year, and people without diabetes tend to lose more weight than those with diabetes

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[DOI] [PubMed] [Google Scholar] 151.Hood J.D., Cheresh D.A