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The authors found that a 14 day course of treatment with metronidazole given to healthy dogs, resulted in significant changes in microbiome composition, including severely decreased amounts of a key beneficial bacteria, Fusobacteria

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MEK/ERK activation and inhibition of peroxisome proliferator-activated receptor- (PPAR) are involved, and this offers an alternative signaling pathway from the GHR (76)

The strategy adopted is reported in a recent paper (72)

You might need to change your dose if your symptoms dont get better or if lab results show youre not getting enough B12

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