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4.3 Oxidative stress and inflammatory pathways Disturbances in mitochondrial energy metabolism and reactive oxygen species (ROS) production are key players in many diseases

The CD4 + T cells that were able to identify the enzymatically modified forms of GAD65 were present in higher frequencies in subjects with T1D when compared to HLA-matched controls without T1D (108)

Role of microRNA-155 in triptolide-induced hepatotoxicity via the Nrf2-dependent pathway

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IV therapy delivers 2-6 times higher doses directly to liver tissue, potentially providing even greater benefits

Given a previous study showing that GPX4 had decreased activity in NEC, it appears that the elevation of GPX2 in NEC could be a response to oxidative stress