Generally, patients remain on the medication for a minimum of 3-4 months, allowing for significant weight loss and the development of healthy lifestyle habits
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doi: 10.1039/d2fo02369e 58 ChoiG.BessmanN
The accumulating body of evidence suggests that the liver toxicity of AFs is mainly associated with oxidative/nitrosative stress, cellular apoptosis, mitochondrial dysfunction, lipid/protein peroxidation, construction of AFs-DNA adducts, DNA damage, induction of genomic mutation, inhibition of tumor suppressor proteins, up-regulation of gene expression, induction of inflammatory signaling pathways (440)
Minami, J
Liu X, George GC, Tsimberidou AM, Naing A, Wheler JJ, Kopetz S , Fu S, Piha-Paul SA, Eng C, Falchook GS, Janku F, Garrett CR, Karp DD, Kurzrock R, Zinner R, Raghav KPS, Subbiah V, Meric-Bernstam F, Hong DS, Overman MJ