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Ethanol-induced neuroinflammation can disrupt the signaling pathways that promote BDNF expression, leading to a vicious cycle where reduced neurotrophic support exacerbates mood dysregulation and cognitive impairments (Hauser et al

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Other reports have emerged ASX to be immunostimulatory: in vitro studies on human lymphocytes have also shown that ASX increases immunoglobulin production in response to T cell-dependent stimuli, as well as increased natural NK cell cytotoxic activity, highlighting the importance of NK cell regulation in serving as an immunosurveillance system against tumors and virus-infected cells [217,218,219]