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On this basis, we will reflect on why abundant preclinical mechanistic insights have failed to translate into significant clinical benefits, and take this as an opportunity to examine the practical challenges and future opportunities faced by current innovative therapeutic strategies targeting this axis

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This cycle of dependency is a common reason for the findings we see during tests

GHK-Cu may prevent oxidative stress in skin by regulating copper and antioxidant gene expression. Oxidative Medicine and Cellular Longevity , 2018, Article ID 3235918

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