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Conversely, in pancreatic ductal adenocarcinoma, synthetic biology approaches have engineered tumor-colonizing bacteria that secrete cysteinase to locally deplete cysteine, thereby dismantling the anti-ferroptotic shield [47]

These experiments provided a rationale for later mouse studies but did not establish a human fat-loss effect

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Patients with type 1 diabetes mellitus are particularly vulnerable to exercise-induced hypoglycemia because exogenous insulin absorption continues regardless of physiological demand, blocking endogenous glucose production

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