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In contrast to BRAF V600E melanoma cell lines, CRC cell lines present higher activity of PI3K/AKT pathway and lower levels of phosphorylated MEK, ERK, RSK, cyclin-D1 and Myc ( V600E in melanoma, dabrafenib and vemurafenib were approved drugs for CRC treatment

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Overall, ICARIA-MM enrolled a more refractory patient population compared with APOLLO: at baseline, patients in ICARIA-MM had received more prior therapy lines (median, 3 vs

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[10] Due to the release of DAMPs and PAMPs, an acute systemic inflammatory state can develop after extensive alcohol intake that dominates the clinical landscape of acute severe alcoholic hepatitis

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