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To reach a more rapid and stable improvement, this psychologically devastating disorder should be treated with a multimodality approach that incorporates photoprotective agents, antioxidant treatments, skin lighteners, exfoliants

Immunogenicity: No participants in clinical trials developed anti-AOD-9604 antibodies, indicating the peptide does not trigger immune responses even with repeated dosing

doi: 10.1016/j.plaphy.2010.08.016 34 GuptaR.ChakrabartyS

Blood was drawn into 5 cc purple-top Vacutainer tubes (containing 1 mg/mL EDTA)

However, prolonged use can lead to dependency, as the brain becomes reliant on these substances to maintain GABA levels

doi: 10.1517/13543780903321490