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Studies have shown that oxidative stress induces endothelial cell apoptosis and disrupts the endothelial glycocalyx, facilitating leukocyte adhesion and extravasation, which worsens tissue damage (Joffre and Hellman, 2021)

Functions of Astrocytic GSH for Neurons and the Brain Astrocytes have a high GSH content which enables these cells to efficiently perform GSHdependent processes, such as the reduction of potential harmful peroxides and removal of xenobiotics (Figure 2) (Dringen et al

doi: 10.1039/C5FO00173K 276 BogolitsynKDobrodeevaLSamodovaAParshinaA

doi: 10.1016/j.psychres.2021.113841 52 ZhaiZGuoY

32 Zinc acts as a cofactor for enzymes of the antioxidant system, and inhibits the enzyme, nicotinamide adenine dinucleotide phosphate oxidase, a prooxidant enzyme, and induces metallothionein synthesis, which is important in the reduction of hydroxyl radicals

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