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1, 2, and 3-ARs, which are coupled to G s , lead to activation of adenylyl cyclase, increasing levels of the second messenger cyclic AMP (cAMP) to promote Protein kinase A (PKA) activation (83) (Figure 2)

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its activity is diminished in cellular assays owing to its swift degradation to adenosine and Hcy by SAH hydrolase (Gao et al., 2021)