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Erythrocyte folate concentrations provide an accurate measure of long-term folate intakes

Options like longevity injections, including NAD+ and B12, may be appropriate for some patients, but theyre typically considered as part of a bigger plan, not as a quick fix

What they found (summary): NAD+ levels decline linearly with age in all tissues Sirtuins are glucose sensors , activated during caloric restriction and fasting The decline in NAD+ leads to pseudohypoxia in aging cells Supplementation with NAD+ precursors in animal models restores sirtuin activity Therapeutic perspectives: NMN, NR, sirtuin activators, CD38 inhibitors Why it matters: This is the reference article for the entire field

In order to elucidate such mechanisms, the aim of this work was to study, in mice with partial IGF-1 deficiency, liver expression of genes involved in glucose and lipid metabolism as well as serum levels of glucose, triglycerides and cholesterol, as well as liver malondialdehyde (MDA) levels, as a marker for oxidative damage

doi: 10.1038/srep34990 409 NiblettSHKingKEDunstanRHClifton-BlighPHoskinLARobertsTKet al

Pivotal trial result: AOD-9604's Phase 2b trial (536 subjects, 24 weeks) failed its primary endpoint