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Reductase deficiency restricted to RBCs

Effects of astragaloside IV on the pharmacokinetics of metoprolol in rats and its mechanism

It was developed in the 1990s by Novo Nordisk and studied extensively in clinical trials for GH deficiency and wasting conditions, though it was ultimately not commercialized in favor of other compounds

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It was designated a Category B IDE study (NCT05683691) on October 12, 2023

Second, GSH is a non-allosteric feedback inhibitor of -glutamate-cysteine ligase, impeding efficient GSH production 24