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When researchers looked at the brains of people with Parkinsons, they discovered that the area that makes dopamine, the substantia nigra, contained as much as 40 percent less glutathione than the rest of the organ

however, no significant changes were observed in LDL or total cholesterol.28 A 2022 meta-analysis focusing on adults with metabolic syndrome risk factors reached similar conclusions, noting modest reductions in LDL cholesterol and systolic blood pressure but overall marginal changes in total cholesterol.29 A broader 2024 review summarizing human and preclinical data suggests that astaxanthin may enhance insulin sensitivity and glucose uptake while supporting lipid metabolism and antioxidant balance, though these findings are based on limited trials and changes in biomarkers.30 These effects are thought to involve activation of Nrf2, a cellular pathway that turns on the bodys own antioxidant defenses, and improved mitochondrial energy metabolism, which may help regulate oxidative stress

CrossRef Recent Updates on Local Ablative Therapy Combined with Chemotherapy for Extrahepatic Cholangiocarcinoma: Photodynamic Therapy and Radiofrequency Ablation Tadahisa Inoue, Masashi Yoneda Current Oncology.2023

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10.1177/0960327115578864 Hum Exp Toxicol