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To test whether palmitoyl-L-carnitine induces intracellular calcium overload alongside mitochondrial fission in neurons, we treated SH-SY5Y cells with either BSA-PC or BSA alone, followed by calcium staining with Fluo-4 AM

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The first hit refers to early metabolic disturbances, including excessive triglyceride accumulation within hepatocytes, insulin resistance, hyperglycemia, and hyperlipidemialeading to steatosis

Short chain fatty acids and methylamines produced by gut microbiota as mediators and markers in the circulatory system

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Administration of CB-1158 (a small molecule inhibitor of arginase) can slow tumor growth rates, block myeloid cell-mediated suppression of T-cell proliferation, and increase the number of tumor-infiltrating CD8 + T cells and NK cells in mouse models of multiple tumors