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Zhang HM, Wakisaka N, Maeda O, Yamamoto T

Written informed consent was obtained from each participant prior to their enrollment in the study

Thus, intrinsic TME conditions sensitized wild-type IDH1 to FDA-approved AG-120 (ivosidenib), and revealed the drug to be a potent single-agent therapeutic in cell culture and diverse in vivo cancer models

The peptide represents a modified version of the 176-191 amino acid sequence from growth hormones C-terminal region, with a tyrosine addition at the N-terminus for stability

The goal is to break open the cells and release their intracellular contents into the lysis buffer