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Description

This phenomenon, similar to what has been proposed in Parkinsons disease [46], suggests a compensatory mechanism where cells increase transcription to compensate for reduced GPX4 protein levels

ITI = 3,000 or 4,000 ms)

There is no simple method to estimate the extent of the latter type of bias (for advanced methods, see Robins 1986, 1987a,b,c)

Future studies leveraging the genetic tractability of Drosophila could further dissect the molecular pathways influenced by such natural compounds, accelerating the discovery of novel AD therapeutics