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Therefore, some scholars used LT 4 intervention as adjuvant therapy in 227 women with AITD who suffered from RM and it was found that low-dose LT 4 treatment can, to some extent, prevent miscarriage ( 4 treatment to pregnant women with a history of hypothyroidism and TPOAb-positivity can improve their live birth rates and reduce miscarriages (Leng et al., 2022)