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Acknowledgements This work was supported in part by a Science Foundation Ireland (SFI) COVID-19 rapid response grant (no

In short, spermidine is a so-called mimetic for starvation, where the benefit is increased longevity similar to that of caloric restriction, which is the gold standard for extending lifespan

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Like in our previous study 15 , mice were sacrificed by decapitation followed by perfusion with 0.9% NaCl after anesthetizing by ketamine at 50 mg/ml, purchased from Renata Ltd., Bangladesh