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In contrast, GDNF activates Sirtuin 1 (SIRT1) through the Ret-ERK1/2 signaling axis, and SIRT1 enhances the transcriptional activity of PGC-1 via deacetylation, thereby improving mitochondrial DNA transcription efficiency and upregulating mitochondrial ribosomal protein expression [67, 92, 93]

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Glutathione helps clear away toxins and waste products by binding to heavy metals and other harmful substances, flushing them out of the body

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