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doi: 10.1677/joe.0.1670505 37 ZhouLZhangMWangYDorfmanRGLiuHYuTet al

In osteoarthritis, inflammation and destruction reinforce each other, forming a vicious cycle of pain, stiffness, and limited mobility

Therefore, statin therapy is not recommended for primary preventative therapy, although it can be used in possibly reducing atherosclerotic cardiovascular risks

964 Natural compounds such as shikonin, resveratrol, vitamin K, and gliotoxin inhibit PKM2, exhibiting substantial anticancer activities