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As critical players in neuroinflammatory and neurodegenerative disease, microglia have become an important target for neurological diseases 11,17

The abnormal extracellular matrix and tumor vasculature surrounding tumor cells result in uneven drug distribution within the tumor, thereby reducing the effective drug concentration ( CAFs play a critical role in tumor progression and drug resistance by secreting growth factors and cytokines that promote tumor cell proliferation and migration

was obtained from the Gene Expression Omnibus (GEO ID: GSE15653)

Serum selenium levels in patients with remission and relapse of graves disease

The absence of long-term safety studies for most NPs, some of which have been fully developed for years, corroborates this dilemma