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Nucleotide-binding oligomerization domain (Nod)-like receptor (NLR) signaling via pattern recognition receptors also depends on PPP flux, which can affect intracellular sensing by macrophages of pathogens, such as Aspergillus ( Furthermore, systemic inflammatory response signals and their downstream propagation is dependent on G6PD expression and activity in macrophages ( Figure 1B-1 )

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Sajdel-Sulkowska EM, Lipinski B, Windom H, Audhya T, McGinnis W

Understanding these different aspects is crucial in optimizing doxorubicin's use and improving outcomes for breast cancer patients

Factors including joint size, disease severity, and individual patient characteristics may influence optimal protocols