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Furthermore, in some cell models, a small proportion of DTCs can resume normal growth and form cell populations even in the presence of drugs, indicating that in a few cases, DTCs can also mutate and cause drug resistance (12)

10.1016/S0300-9629(96)00166-1 Res

[DOI] [PubMed] [Google Scholar] 5.Bergmeister K.D., Groe-Hartlage L., Daeschler S.C., Rhodius P., Bcker A., Beyersdorff M., Kern A.O., Kneser U., Harhaus L

And so I think it was just making his mitochondrial function worse

Neurotox Res 39(6):21862193

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