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pharmaceutics 478 , 517529 (2015)

The mechanism is related to metabolic regulation and increased chemosensitivity of cancer cells: by inhibiting NNMT, the product disrupts the energy supply of cancer cells, making them more vulnerable to chemotherapy, while protecting the metabolic balance of normal cells and reducing side effects

102,103 Exercise-induced IGF1 activates IGF1 receptor (IGF1R) tyrosine kinase, which can recruit the SH2 domain-containing protein such as the p85 regulatory subunit of Class IA PI3K

doi: 10.1101/cshperspect.a028431 123 FluhrerRGrammerGIsraelLCondronMMHaffnerCFriedmannEet al

This review highlights how the probiotic field is advancing beyond traditional applications to encompass NGPs, live biotherapeutics, genetically engineered microbes, and rational microbial consortia