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Results SIRT1 expression and activity is downregulated following noise exposure To systematically explore the impact of acoustic trauma on SIRT1 in mouse cochlear hair cells, 5-week-old C57BL/6 J mice were subjected to noise at 108 dB SPL for 2 h, based on a previously demonstrated protocol to induce NIHL in mouse models [28]

Turner JE, Brum PC

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Breakthrough computational tools such as AlphaFold3 169,170 and RoseTTAFold All-Atom 171 have opened new opportunities for GPCR-targeted drug discovery, greatly advancing structure-based drug development

[Google Scholar] 28.Platt R

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