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doi: 10.3389/fendo.2026.1781679 Received 06 January 2026 Revised 16 February 2026 Accepted 19 February 2026 Published 11 March 2026 Volume 17 - 2026 Edited by Alpo Juhani Vuorio, University of Helsinki, Finland Reviewed by Diana Rodrguez Vera, Instituto Politecnico Nacional, Mexico Nana Afia Ntim, University of Ghana, Ghana Updates Copyright 2026 Zhu, Qu, Li, Deng, Shen and Chen

a combination of 1 mM IBMX, 1 M dexamethasone, and 10 g/ml of insulin in media were added to fully confluent 3T3-L1 fibroblasts for three days (days 0-3) to initiate differentiation

They do not constitute clinical evidence of efficacy or safety in humans, and all reference to biological activity pertains strictly to preclinical research settings

Metformin improves ovarian follicle dynamics by reducing theca cell proliferation and cyp-17 expression in an androgenized rat model

Astrocytes take up K + in areas with high concentrations through gap junctions between adjacent cells and release it in areas with lower concentrations (78, 81)

These consequences may impair neurological health and cognitive function