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In general, the reactivity of Michael acceptor influenced by the presence of an electron-withdrawing ester group at C4, an ester vs amide at C2, ring strain (5- versus 6-membered ring) correlated with inhibitor potency

10.1053/j.gastro.2019.11.312 22 FanY.WangD.HuY.LiuJ.GaoH.WangY.et al (2011)

By interacting with growth hormone-releasing hormone receptors (GHRHr), GHRP-2 activates somatotroph cells, prompting them to increase the synthesis and secretion of growth hormone (GH)