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This gives rise to specific limitations that need to be borne in mind: Preclinical models predominate cell cultures and animal studies

10.1074/jbc.275.15.10761 47 RaibleD

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Tang, J

However, with IBD-current biologic therapies, all these mean some patients primary non-responders, experience a loss of response, intolerance or side effects, defining the urgent unmet need for novel treatments (13, 14)