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Neither the accessibility of the Grx(SSR) sulfur atoms (Fig

Figure 6 3.8 CB-839 did not improve cytotoxicity in combination with venetoclax, AZD-5991, and ibrutinib in primary CLL lymphocytes We then tested these drug combinations in the primary CLL cells, both in the native condition ( Figure 7A ) and in media supplemented with cytokines (CD40 ligand and interleukin-4) to mimic the microenvironment and maintain viability ( Figure 7B )

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Follow-up Repeat broad markers after 6-12 weeks if symptoms change, inflammation is part of the context, or the protocol continues

Our previous study also identified a significant association between the NNMT genetic variant at rs1941404 and T2D in the Chinese Han population (Li et al., 2018)