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They use it for chronic medical problems or diseases accompanied and complicated by diabetes mellitus

In conclusion, based on randomized controlled trials, high doses of vitamin B12 have not been shown to be associated with the risk of fractures

Pharmacological aspects of natural quercetin in rheumatoid arthritis

Comparative study of subacute combined degeneration of the spinal cord due to nitrous oxide abuse and vitamin B12 deficiency

If overdose is suspected or if neurologic symptoms emerge, stop further dosing and seek medical evaluation

However, the bulk of research is preclinical, with a significant lack of high-quality clinical trials