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Unlike circumscribed gliomas, which have well-defined margins and generally better prognosis, diffuse gliomas are characterized by extensive invasion into normal brain tissue, limiting the effectiveness of surgical resection

Similar effects were observed in the brain of mice exposed to aspartame at doses up to 45 mg/kg bw or 5.625 mg/kg bw per day by single or multiple (for 2 weeks) subcutaneous injections, respectively

10.1126/science.286.5438.304

Gruzelier JH, Foks M, Steffert T, Chen ML, Ros T

According to the specific oxidation position, the 12/15-LOX is in charge of catalyzing AA to 12-/15- hydroperoxyeicosatetraenoic acid (12-/15-HpETE) (Snodgrass and Brune, 2019)