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While the etiology is still unknown, many factors may contribute to disease development, including genetic predisposition, vascular dysregulation, T H 1/T H 2 imbalance with chemokines and cytokines associated with interferon- and profibrotic pathways as well as certain environmental factors

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Based on the phylogenetic tree and the comparison of morphological, cultural, and physiological characteristics with its closest relatives, strain NEAA-5 showed the highest similarity (98.42%) to Streptomyces viridochromogenes NRRL B-1511

doi: 10.1038/ni.1990 Summary Keywords glioblastoma, tumor-associated macrophage, immunotherapy, tumor microenvironment, immunosuppression Citation Wang Z, Zhong H, Liang X and Ni S (2022) Targeting tumor-associated macrophages for the immunotherapy of glioblastoma: Navigating the clinical and translational landscape