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Oxidative stress plays a vital role in the development of obesity and dyslipidaemia, insulin resistance and diabetes, hypertension via various mechanisms associated with ROS-led inflammatory response and endothelial dysfunction

Drug site III A third binding site has also been discovered within subdomain IB as the primary binding pocket of a photoisomer of bilirubin, hemin, the steroid antibiotic such as fusidic acid, and sulphonamide derivatives (Zsila, 2013

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