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A randomised controlled trial is considered the gold standard of clinical evidence

doi: 10.1038/s41467-019-11665-0

From a clinic governance perspective, that is a meaningful distinction

Using low-dead-space syringes can improve accuracy

Pernicious anaemia , an autoimmune condition affecting approximately 2% of the UK population over 60 (and about 0.10.2% overall), destroys gastric parietal cells, eliminating intrinsic factor production and severely impairing B12 absorption