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Accumulating in-vitro and in-vivo data show that ferroptosis not only participates in OSCC initiation and progression but is also closely associated with immune escape, chemoresistance, and poor prognosis

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Macrophage activation and foam cell formation may explain the elevated CRP serum levels and contribute to disease progression (Figure 3)

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Environmental factors, such as oxidative stress, exercise, temperature stress (cold or heat), cell division, regeneration and differentiation, can promote mitochondrial biogenesis