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(B) Asymmetric reduction of EAA catalysed by soluble and immobilised multi-functional biocatalysts

Overexpression resulted in elevated levels of 12-( S )-HETE and 13-( S )-HODE in the mice, leading to several pathological changes: increased AHR, heightened oxidative stress in the mitochondria of bronchial epithelial cells, goblet cell metaplasia, increased sub-epithelial fibrosis, and augmented recruitment of inflammatory cells to the bronchovascular regions

These modifications can lead to loss of protein function and cellular dysfunction [177]

reported that apatinib reduced the expression of GPX4, thereby inhibiting the proliferation of GC cells and multidrug-resistant GC (Zhao et al., 2021)